CHERP anticorps (Cytosolic)

N° du produit ABIN7884835

L’anticorps anti-CHERP Polyclonal Lapin est utilisé pour la détection de CHERP dans des échantillons de Souris et Rat. Il a été validé pour WB, IHC et IF.

Aperçu rapide pour CHERP anticorps (Cytosolic) (ABIN7884835)

Antigène: CHERP (Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHERP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Détail du produit anti-CHERP anticorps

Épitope: AA 669-684, Cytosolic

Fonction: A Rabbit Polyclonal Antibody to CHERP

Homologie: Rat,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KLEDHEYKPLDPKDIR, corresponding to amino acid residues 669-684 of mouse CHERP

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:1500

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235001)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CHERP

Antigène: CHERP (Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP))

Autre désignation: Calcium homeostasis endoplasmic reticulum protein

Sujet:

Synonyms: Calcium homeostasis endoplasmic reticulum protein, SR-related CTD-associated factor 6, SCAF6

Description: CHERP (calcium homeostasis endoplasmic reticulum protein) is a ubiquitously expressed integral sarco/endoplasmic reticulum (SR/ER) membrane protein. CHERP protein consist of 916 amino acid in humans and its structure containing a Pro-rich region and a segment of Arg-Ser dipeptide repeats (an RS domain) near the C terminus, and an RNA recognition motifs (RRMs)1-3.CHERP acts as a regulator of both major families of endoplasmic reticulum Ca2+ channels, inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs). CHERP is responsible for the regulation of intracellular Ca2+ mobilization in human cells and is involved in neuroblastoma cell proliferation, apoptosis and tumorigenicity1,2.CHERP co-localizes with IP3 receptors throughout the cytoplasmic and perinuclear regions in human erythroleukemia cells and in Jurkat cells. CHERP is also detected in the nucleoplasm with prominent accumulation at nuclear speckles1,2. CHERP co-localizes with endogenous ryanodine receptor type 1 (RyR1) in the sarcoplasmic reticulum of rat soleus muscle. Studies of CHERP knockdown reveal decreased intracellular Ca2+ mobilization, cell growth and proliferation2,3.

ID gène: 27967

UniProt: Q8CGZ0