CNR2 anticorps (3rd Intracellular Loop)

N° du produit ABIN7884843

Cet anticorps Lapin Polyclonal détecte spécifiquement CNR2 dans WB et IHC. Il présente une réactivité avec des échantillons de Rat et Souris.

Aperçu rapide pour CNR2 anticorps (3rd Intracellular Loop) (ABIN7884843)

Antigène: CNR2 (Cannabinoid Receptor 2 (CNR2))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CNR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Détail du produit anti-CNR2 anticorps

Épitope: 3rd Intracellular Loop, AA 228-242

Fonction: A Rabbit Polyclonal Antibody to Cannabinoid Receptor 2

Homologie: Mouse - identical Human - 14 out of 15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DRQVPGIARMRLDVR, corresponding to amino acid residues 228-242 of rat CB2 receptor

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100-1:400

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235032)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CNR2

Antigène: CNR2 (Cannabinoid Receptor 2 (CNR2))

Autre désignation: CB2

Sujet:

Synonyms: CB2, CNR2

Description: Cannabinoids have been used as pain relievers in Eastern medicine for many years.1 To date, two specific cannabinoid receptors have been identified: cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).2 The cannabinoid receptors can be distinguished by their amino acid sequence, signaling mechanisms and tissue distribution.2 Both receptors belong to the G-protein coupled receptor superfamily and are coupled to Gi/0 G protein.2,3The CB2 receptor is highly expressed in cells of the immune system such as macrophages, lymphocytes natural killer cells and mast cells but has also been shown to be expressed, by both, in situ-hybridization and in immunohistochemistry, in spleen, thymus, and pancreas.1,2,4 CB2 expression in the brain is still much less characterized than that of CB1. Recently, it was demonstrated that CB2 is expressed in the brain and might have a role in controlling fundamental processes such as proliferation and survival of neural cells.5,6Overexpression of CB2 was reported in several cancers such as prostate, glioma and acute myeloid leukemias.6 In human astrocytoma a direct relationship between CB2 expression and tumor malignancy was demonstrated. Activation of CB2 in vivo by its agonist JWH-133, completely blocked cell growth. In C6 glioma, it was shown that activation of the CB2 by JWH-133 resulted in the internalization of only the CB2 and not CB1 leading to apoptosis of the cells. This may well be a new approach for the treatment of glioma.7

ID gène: 57302

UniProt: Q9QZN9