CD81 anticorps (Extracellular, Loop 2)

N° du produit ABIN7884853

L’anticorps anti-CD81 Polyclonal Lapin est utilisé pour la détection de CD81 dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS, WB, IHC et LCI.

Aperçu rapide pour CD81 anticorps (Extracellular, Loop 2) (ABIN7884853)

Antigène: CD81

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD81 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-CD81 anticorps

Épitope: AA 190-201, Extracellular, Loop 2

Fonction: A Rabbit Polyclonal antibody to CD81 (extracellular)

Homologie: Mouse,rat - 11 out of 12 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: CHQKIDDLFSGK, corresponding to amino acid residues 190 - 201 of human CD81

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: 2.5-5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CD81

Antigène: CD81

Autre désignation: Tetraspanin-28

Sujet:

Synonyms: Tetraspanin-28, TSPAN28, Target of the Antiproliferative Antibody 1, TAPA-1

Description: Cluster of differentiation 81, CD81, also known as Tetraspanin-28, Tspan28, and target of the antiproliferative antibody 1, TAPA-1, is a transmembrane (TM) protein, member of the tetraspanin family, and plays a role in intercellular interactions and cellular trafficking.1CD81 is composed of 236 amino acids, four TM regions, intracellular N- and C-termini, small (EC1) and large (EC2) extracellular loops, a short intracellular loop between TM2 and TM3, and is characterized by a bound cholesterol molecule in an intramembrane pocket between the two pairs of TM helices capped by the EC2 domain. The binding of cholesterol alters the conformation of the protein, a process which is exploited by certain viruses to enter cells. CD81 serves as a co-receptor for several viruses, including hepatitis C (HCV), human immunodeficiency virus type 1 (HIV-1), herpes simplex virus 1 (HSV-1), influenza A (IAV), and Chikungunya, as well as certain bacteria and parasites. CD81 can interact with other TM proteins to form clusters and higher-order protein complexes.1,2CD81 is highly conserved in mammals, expressed on all primary B-lineage cells from early B-cell development stages, and associates with CD19 on the cell surface. CD81 engagement on mature human B-cells induces an antiproliferative effect.3CD81 is involved in neurotransmission, cell signaling, cell proliferation, and protein trafficking, as well as the immune, reproductive, genitourinary, and auditory systems. CD81 is also implicated in oncology, viral infection, and inflammation.1,2

ID gène: 975

UniProt: P60033

Pathways: Inositol Metabolic Process, Hepatitis C