CLCN2 anticorps (C-Term, Intracellular)

N° du produit ABIN7884873

Cet anticorps Lapin Polyclonal détecte spécifiquement CLCN2 dans WB, IHC, IF et IC. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CLCN2 anticorps (C-Term, Intracellular) (ABIN7884873)

Antigène: CLCN2 (Chloride Channel 2 (CLCN2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLCN2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Classe de qualité: Carrier-free, KO Validated

Détail du produit anti-CLCN2 anticorps

Épitope: AA 888-906, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to CLC-2 (CLCN2) Channel

Homologie: human - 17, guinea pig - 15,swine - 18,19 amino acid residues identical,Mouse - identical, rabbit

Purification: Affinity purified on immobilized antigen.

Immunogène: RSRHGLPREGTPSDSDDKC, corresponding to amino acid residues 888-906 of rat CLC-2.

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235082)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CLCN2

Antigène: CLCN2 (Chloride Channel 2 (CLCN2))

Autre désignation: Chloride channel 2

Sujet:

Synonyms: Chloride channel 2, ClC2

Description: CLC-2 is a member of the voltage-dependent Cl- channel (CLC) family that includes nine known members in mammals. CLC channels can be classified as plasma membrane channels and intracellular organelle channels. The first group includes the CLC-1, CLC-2 CLC-Ka and CLCKb channels. The second group comprises the CLC-3, CLC-4, CLC-5, CLC-6 and CLC-7.CLC channels that function in the plasma membrane are involved in the stabilization of membrane potential and in transepithelial transport. The presumed function of the intracellular CLC channels is support of the acidification of the intraorganellar compartment. In this regard, recent reports indicate that ClC-4 and ClC-5 (and by inference ClC-3) can function as Cl-/H+ antiporters.1, 2The functional unit of the CLC channels is a dimer with each subunit forming a proper pore. Although the crystal structure of bacterial CLC channels was resolved, the topology of the CLC channels is complex and has not been fully elucidated. It is generally accepted that both the N- and C- terminus domains are intracellular while the number and configuration of the transmembrane domains vary greatly between different models. 1,2CLC-2 is widely distributed with prominent expression in brain, kidney, lung and the gastrointestinal system. Mutations in the CLC-2 channel gene detected in humans are associated with idiopathic generalized epilepsies while disruption of the ClC-2 gene in mice is associated with testicular and retinal degeneration. 3,4

ID gène: 29232

UniProt: P35525