CRMP1 anticorps (Intracellular)

N° du produit ABIN7884890

Cet anticorps anti-CRMP1 Polyclonal Lapin (ABIN7884890) détecte spécifiquement CRMP1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CRMP1 anticorps (Intracellular) (ABIN7884890)

Antigène: CRMP1 (Collapsin Response Mediator Protein 1 (CRMP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRMP1 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-CRMP1 anticorps

Épitope: AA 481-496, Intracellular

Fonction: A Rabbit Polyclonal Antibody to CRMP-1

Homologie: Mouse - identical, human - 12,16 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RVRIRSKVFGLHSVSR, corresponding to amino acid residues 481-496 of rat CRMP1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235158)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CRMP1

Antigène: CRMP1 (Collapsin Response Mediator Protein 1 (CRMP1))

Autre désignation: CRMP-1

Sujet:

Synonyms: CRMP-1, Collapsin response mediator protein 1, Dihydropyrimidinase-related protein 1, DRP-1, Dpysl1, Dihydropyrimidinase-like 1, Ulip3, Unc-33-like phosphoprotein 3

Description: Collapsin response mediator proteins (CRMPs) are a family of cytosolic phosphoproteins that were originally identified in developing nervous tissue. They are characterized as intracellular mediators of Semaphorin 3A signaling pathway, which is involved in axon differentiation during neural development.The CRMP family includes five members, CRMP-1 to CRMP-5. All five isoforms share a significant similarity in sequence with liver dihydropyrimidinase (DHPase) and with each other. CRMP-1 to CRMP-4 share 75 % identical sequence, while CRMP-5 shares 50 % identity with the other CRMPs.CRMP-1 is involved in cortical neuronal migration through reelin signaling. CRMP-1 inhibits the migration and invasion of non-small cell lung cancer (NSCLC). CRMP-1 includes a long form isoform, LCRMP-1, which promotes filopodia formation, cancer cell migration and invasion, resulting in poor clinical outcomes in NSCLC patients, therefore the long form is considered to be an invasion enhancer in NSCLC1-3.Human CRMP-1 overall structure is very similar to mouse CRMP-1. The human protein generally comprises a heterotetrameric assembly with a randomly coiled link that connects the protomers to each other. The proteins can form homotetramers when purified from bovine brain. CRMPs contains a positively charged C-terminal region that is highly susceptible to proteolysis2,3.

ID gène: 25415

UniProt: Q62950