Complexin 1 anticorps (Intracellular, N-Term)

N° du produit ABIN7884894

Cet anticorps Lapin Polyclonal détecte spécifiquement Complexin 1 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Complexin 1 anticorps (Intracellular, N-Term) (ABIN7884894)

Antigène: Complexin 1 (CPLX1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Complexin 1 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-Complexin 1 anticorps

Épitope: AA 14-27, Intracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Complexin-1 and Complexin-2

Homologie: Complexin 1: Mouse,human - identicalComplexin 2: Rat,mouse,human - 13,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KDMGKMLGGDEEKD, corresponding to amino acid residues 14-27 of rat Complexin-1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Complexin 1

Antigène: Complexin 1 (CPLX1)

Autre désignation: Complexin 1

Sujet:

Synonyms: Complexin 1, Complexin I, Synaphin-2, Complexin 2, Complexin II, Synaphin-1

Description: Complexins (1 through 4) are small cytosolic proteins that bind tightly to a complex of SNARE proteins to regulate synaptic vesicle membrane fusion via its interaction with synaptotagmin. Complexins activate the quick release of neurotransmitters, triggered by calcium release. They also regulate the "spontaneous release" of neurotransmitters1-3.Complexins are evolutionarily conserved in mammals, Drosophila, and Caenorhabditis elegans1,2. They are divided into four structural domains: flexible N- and C-terminal domains, an accessory domain, and a central α-helical domain. The N-terminal domain plays a role in activation of fast synchronous release in murine neurons and in isolated chromaffin cells. The C-terminal domain binds to phospholipids and is important for regulating spontaneous release in neuronal cultures and suppressing Ca2+-independent fusion in vitro. The accessory domain is necessary for regulating spontaneous release and the central domain is required for all functions1,2.

ID gène: 64833, 116657

UniProt: P63041, P84087

Pathways: Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport