Contactin 1 anticorps (Extracellular, N-Term)

N° du produit ABIN7884895

L’anticorps anti-Contactin 1 Polyclonal Lapin est utilisé pour la détection de Contactin 1 dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, IHC et IF.

Aperçu rapide pour Contactin 1 anticorps (Extracellular, N-Term) (ABIN7884895)

Antigène: Contactin 1 (CNTN1)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Contactin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Détail du produit anti-Contactin 1 anticorps

Épitope: AA 947-961, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Contactin-1 (extracellular)

Homologie: Mouse - identical, human - 14,15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RPDGQHDGKLFSTHK, corresponding to amino acid residues 947 - 961 of rat Contactin-1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235161)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Contactin 1

Antigène: Contactin 1 (CNTN1)

Autre désignation: Neural cell surface protein F3

Sujet:

Synonyms: Neural cell surface protein F3, Glycoprotein GP135, CNTN1

Description: Contactin-1 (CNTN1), also known as F3/Contactin a cell adhesion molecule, is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein involved in neuronal development, synaptic maintenance and organization of neuronal networks. CNTNs are a subpopulation of molecules belonging to the immunoglobulin (Ig) superfamily, which includes six members: CNTN1, TAG-1/CNTN2, BIG-1/CNTN3, BIG-2/CNTN4, NB-2/CNTN5 and NB-3/CNTN61,2.In mammals, contactin-1 is mostly localized in the peripheral and central neural system. It is highly expressed at the axonal level and mediates various functions in both glial and neuronal cells, it is involved in neuronal and glial development and differentiation, myelination, synaptogenesis and synaptic function1.Contactin-1 expression profile differs in various brain regions and, within each area, it changes depending upon the cell type. For example, in the cerebellar cortex contactin-1 is predominant in granule cells in earlier developmental stages, whereas its activation is delayed in Purkinje neurons. In the hippocampus, it is detected on pyramidal neurons of CA1-CA3 fields and in granule layers of Dentate Gyrus (DG) where its expression persists in postnatally developed neurons. Hippocampal contactin-1 is highly expressed in the developing hippocampus, it progressively increases during postnatal life, but it declines during aging, paralleling cognitive impairment. This suggests that contactin-1 might play a role in memory processes, in line with studies indicating its involvement in neurotransmitter release and some forms of plasticity1.The role of contactin-1 in neurotransmitter release has been linked with its capability to regulate synaptic vesicle exocytosis. Contactin-1 overexpression had been shown to induce an increase of cAMP-Responsive Element Binding (CREB) phosphorylation, enhanced hippocampal-dependent LTP and memory especially in 12-months-old mice, where neurogenesis is particularly evident. Also, contactin-1 overexpression counteracts apoptosis, and induces an increase of the antiapoptotic- and neuroplasticity-pathway BDNF/CREB/Bcl-21,3.Contactin-1 plays an important role in cancer progression. The expression of contactin-1 is upregulated in primary lesions, and its expression level correlates with tumor metastasis in cancer patients. Studies have demonstrated that contactin-1 also plays a key role in diseases not related to the nervous system, and its most notable function is its participation in cancer progression, in cancers such as esophageal squamous cell carcinoma (ESCC), GC, lung adenocarcinoma, oral squamous cell carcinoma (OSCC), hepatocellular carcinoma and prostate cancer2,3.

ID gène: 117258

UniProt: Q63198