CNTNAP2 anticorps (C-Term, Intracellular)

N° du produit ABIN7884897

Cet anticorps Lapin Polyclonal détecte spécifiquement CNTNAP2 dans WB, IHC et IF. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour CNTNAP2 anticorps (C-Term, Intracellular) (ABIN7884897)

Antigène: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CNTNAP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Détail du produit anti-CNTNAP2 anticorps

Épitope: AA 1315-1331, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Caspr2

Homologie: Mouse,rat - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DPNFTETIDESKKEWLI, corresponding to amino acid residues 1315-1331 of human Caspr2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235165)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CNTNAP2

Antigène: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Autre désignation: Contactin-associated protein-like 2

Sujet:

Synonyms: Contactin-associated protein-like 2, CNTNAP2

Description: Contactin-associated protein 2 (Caspr2) is a member of the neurexin superfamily, a group of transmembrane proteins that mediate cell-to-cell interactions in the nervous system1,2.Neurexins are adhesion molecules expressed mainly at presynaptic locations that form trans-synaptic cell-to-cell adhesion complexes via binding to their postsynaptic partners, the neuroligins2.Caspr2, like other neurexin proteins, is a type I membrane protein that contains epidermal growth factor repeats, laminin G domains, an F5/8 type C domain, and fibrinogen-like domains in its extracellular domain1,2.Caspr2 is localized at the juxtaparanodes of myelinated axons, a specialized region that mediates interactions between neurons and glia during nervous system development1.The juxtaparanodal region is highly enriched with heteromultimers of the K+ channels KV1.1, KV1.2, and their cytoplasmic KVβ2 subunit, which may help in axon conduction stabilization and the maintenance of the internodal resting potential1. Caspr2 is essential for the targeted localization of these channels in the juxtaparanodal regions. Indeed, targeted disruption of Caspr2 resulted in a marked reduction in the accumulation of K+ channels at the juxtaparanodes in both peripheral and central nervous system axons3.Moreover, mutations in the Caspr2 gene have been implicated in multiple neurodevelopmental disorders, including Tourette syndrome, schizophrenia, epilepsy, autism, attention-deficit hyperactivity disorder and mental retardation4-6.

ID gène: 26047

UniProt: Q9UHC6