Dopamine Receptor d1 anticorps (C-Term, Intracellular)

N° du produit ABIN7884917

Cet anticorps anti-Dopamine Receptor d1 Polyclonal Lapin (ABIN7884917) détecte spécifiquement Dopamine Receptor d1 dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Rat et Souris.

Aperçu rapide pour Dopamine Receptor d1 anticorps (C-Term, Intracellular) (ABIN7884917)

Antigène: Dopamine Receptor d1 (DRD1) (Dopamine Receptor D1 (DRD1))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dopamine Receptor d1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Détail du produit anti-Dopamine Receptor d1 anticorps

Épitope: AA 372-385, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to D1 Dopamine Receptor

Homologie: Mouse,dog,pig - identical, human - 13,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: SSHHEPRGSISKDC, corresponding to amino acid residues 372-385 of rat DRD1 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235235)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Dopamine Receptor d1

Antigène: Dopamine Receptor d1 (DRD1) (Dopamine Receptor D1 (DRD1))

Autre désignation: DRD1

Sujet:

Synonyms: DRD1, D(1A) dopamine receptor

Description: The D1 dopamine receptor (D1 receptor, DRD1) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and hormone secretion. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson's disease and Schizophrenia1.All five dopamine receptors belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily.Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes)1.The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity1.The D1 receptor is widely distributed throughout the brain with the highest expression in the cerebral cortex and striatum. In the periphery the D1 receptor has been detected in the adrenal cortex, kidney and heart.Functionally, the D1 receptor has been implicated in the regulation of both locomotor and cognitive functions including the maintaining of spontaneous motor behaviors, the control of working memory and cognition as well as the regulation of craving and reward pathways.In addition, the D1 receptor plays an important role in the pathogenesis of hypertension by regulating epithelial Na+ transport and by interacting with vasoactive hormones/humoral factors, such as aldosterone and angiotensin1,2.

ID gène: 24316

UniProt: P18901

Pathways: cAMP Metabolic Process, Inositol Metabolic Process, Protein targeting to Nucleus, Feeding Behaviour, Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity