Ephrin A2 anticorps (Extracellular)

N° du produit ABIN7884943

L’anticorps anti-Ephrin A2 Polyclonal Lapin est utilisé pour la détection de Ephrin A2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IF, FACS, IHC et LCI.

Aperçu rapide pour Ephrin A2 anticorps (Extracellular) (ABIN7884943)

Antigène: Ephrin A2 (EFNA2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ephrin A2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Ephrin A2 anticorps

Épitope: AA 71-84, Extracellular

Fonction: A Rabbit Polyclonal Antibody to Ephrin-A2

Homologie: Rat - identical, human - 13,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)HYGAPLPPAERMER, corresponding to amino acid residues 71-84 of mouse Ephrin-A2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:400

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235305)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Ephrin A2

Antigène: Ephrin A2 (EFNA2)

Autre désignation: EPH-related receptor tyrosine kinase ligand 6

Sujet:

Synonyms: EPH-related receptor tyrosine kinase ligand 6, LERK6, CEK7-ligand, EFNA2

Description: Eph receptor tyrosine kinases family and their ligands, ephrins, are membrane proteins that primarily regulate cell to cell repulsion and cell adhesion and movement by modulating the organization of the actin cytoskeleton mainly through Rho family GTPases. Eph receptors and ephrin ligand signaling regulaes many aspects of cell interaction in the developing neocortex, including migration and axonal target recognition. Ephrin signaling plays an important role in guiding neurons and their projections during embryonic development1,2.In mammals, the Eph receptor tyrosine kinases family has 14 members that are divided into 2 subclasses, the EphA (A1-A8 and A10) and EphB (B1-B4 and B6). This division is based on the sequence similarity of their extracellular domains. EphA receptors bind to glycosylphosphatidyl inositol-anchored ephrin-A ligands, and EphB receptors bind to transmembrane ephrin-B proteins. The ephrin-A proteins include five members ephrin-A1 to ephrin-A5 whereas ephrin-B proteins include three ephrin-B1 to ephrin-B32,3.Ephrin-A2 protein is abundantly expressed in retinal axons. Mutations in Ephrin-A2 disrupts topographic ordering of projections in the developing visual system. A knockout of ephrin-A2 in adult mice shows focal patches of disorganized neocortical laminar architecture, ranging in severity from reduced neuronal density to a complete lack of neurons1,2.

ID gène: 13637

UniProt: P52801