GALR2 anticorps (3rd Intracellular Loop)

N° du produit ABIN7885009

L’anticorps anti-GALR2 Polyclonal Lapin est utilisé pour la détection de GALR2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC et IF.

Aperçu rapide pour GALR2 anticorps (3rd Intracellular Loop) (ABIN7885009)

Antigène: GALR2 (Galanin Receptor 2 (GALR2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GALR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Détail du produit anti-GALR2 anticorps

Épitope: 3rd Intracellular Loop, AA 223-235

Fonction: A Rabbit Polyclonal Antibody to Galanin Receptor Type 2

Homologie: Rat - identical, human - 11,13 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)GSGSQRAKRKVTR, corresponding to amino acid residues 223-235 of mouse Galanin receptor type 2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235477)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur GALR2

Antigène: GALR2 (Galanin Receptor 2 (GALR2))

Autre désignation: Galanin receptor type 2

Sujet:

Synonyms: Galanin receptor type 2, GALNR2, GAL2R

Description: Galanin is a neuropeptide, consisting of 29-30 amino acid residues, involved in the regulation of cognition, mood, feeding, seizure activity and pain. Galanin exerts its action via three known receptors, the Galanin receptor type 1 (GALR1), Galanin receptor type 2 (GALR2) and Galanin receptor type 3 (GALR3). The Galanin receptors belong to the G-protein coupled receptor superfamily.1-4GALR2 is widely expressed in the brain (with highest levels of mRNA found in the hypothalamus, hippocampus, amygdala and pyriform cortex) and in peripheral tissues such as the small intestine, heart, kidney, and liver. High levels of GALR2 expression were also found in rat dorsal root ganglia.1GALR2 activation increases inositol phosphate hydrolysis, mediates the release of Ca2+ into the cytoplasm from intracellular stores, and opens Ca2+-dependent chloride channels in a PTX-resistant manner, indicating that GALR2 couples to Gq/11 proteins.5

ID gène: 14428

UniProt: O88854

Pathways: cAMP Metabolic Process, Inositol Metabolic Process, Feeding Behaviour