LYNX1 anticorps (Extracellular, N-Term)

N° du produit ABIN7885120

L’anticorps anti-LYNX1 Polyclonal Lapin est utilisé pour la détection de LYNX1 dans des échantillons de Souris, Humain et Rat. Il a été validé pour WB, FACS, IF et IHC.

Aperçu rapide pour LYNX1 anticorps (Extracellular, N-Term) (ABIN7885120)

Antigène: LYNX1 (Ly6/Neurotoxin 1 (LYNX1))

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LYNX1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Détail du produit anti-LYNX1 anticorps

Épitope: AA 26-38, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Lynx1

Homologie: rat - 12,Mouse,13 amino acid residues identical, human - 11

Purification: Affinity purified on immobilized antigen.

Immunogène: CAYNGDN(S)FKPMR, corresponding to amino acid residues 26-38 of mouse Lynx1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:1000

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235894)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur LYNX1

Antigène: LYNX1 (Ly6/Neurotoxin 1 (LYNX1))

Autre désignation: Ly-6/Neurotoxin-like protein 1

Sujet:

Synonyms: Ly-6/Neurotoxin-like protein 1, Endogenous prototoxin LYNX1

Description: Lynx1 is a member of the Ly-6/neurotoxin gene superfamily (Lynx family) of proteins that feature a three-looped toxin fold and a cysteine rich motif, structural characteristics that are shared with the snake venom toxin α-bungarotoxin1.Lynx1 is expressed in large projection neurons in the hippocampus, cortex, and cerebellum. Initial analysis of the functional consequence of genetic ablation of Lynx1 in mice revealed that Lynx1 is an allosteric modulator of various nicotinic receptors that affects their kinetics, decreases their agonist affinities, and increases their desensitization to overall limit their activation. Lynx1 can serve as a protective measure against neurotoxicity through agonist-induced overstimulation2. In fact, deletion of Lynx1 eventually leads to neurodegeneration in aged mice3.Collectively the findings regarding Lynx1 suggest a direct relationship between plasticity regulation and nicotinic signaling, and underline the significance of fine tuning of nicotinic tone to vastly control the development of brain functions.Lynx1 activity was shown to be related to the pathophysiology of Alzheimer's disease as well as cholinergic activity in healthy and tumor cells of bronchial epithelium4.

ID gène: 23936

UniProt: P0DP60