MCT3 anticorps (C-Term, Intracellular)

N° du produit ABIN7885146

Cet anticorps Lapin Polyclonal détecte spécifiquement MCT3 dans WB. Il présente une réactivité avec des échantillons de Rat et Souris.

Aperçu rapide pour MCT3 anticorps (C-Term, Intracellular) (ABIN7885146)

Antigène: MCT3 (Monocarboxylate Transporter 3 (MCT3))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCT3 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-MCT3 anticorps

Épitope: AA 421-434, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Monocarboxylate Transporter 3

Homologie: Mouse - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RSAEGGASDPEDVE, corresponding to amino acid residues 421-434 of rat MCT3

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur MCT3

Antigène: MCT3 (Monocarboxylate Transporter 3 (MCT3))

Autre désignation: Monocarboxylate transporter 3

Sujet:

Synonyms: Monocarboxylate transporter 3, Monocarboxylic acid transporter 3, SLC16A8

Description: Proton-linked monocarboxylate transporters (MCTs) are a family of highly homologous trans-membrane symporters, involved in the transportation of monocarboxylic acids across the plasma membrane such as: lactate, pyruvate, branched-chain oxoacids derived from leucine, valine, and isoleucine, ketone bodies, acetoacetate, β-hydroxybutyrate and acetate. Thus, MCTs play an important role in metabolic communication among cells and in mammalian metabolism.MCT3 is encoded by the Slc16a8 gene and contains at least nine members in humans1. Structurally, MCTs have 12 transmembrane spanning domains with cytoplasmic NH2- and COOH-terminals. The COOH-terminal regions are not well conserved among the MCTs isoforms while the membrane spanning domains share the greatest sequence identity3,4. Findings suggest that the N-terminal domain is more important for energy coupling, membrane insertion and correct structure maintenance, whereas the C-terminal domain is more important for the determination of substrate specificity1.MCT3 is expressed in the retinal pigment epithelium, preferentially expressed in the basolateral membrane in the adult and in choroid plexus epithelium where it plays a role in regulating pH and lactate concentrations in the outer retina. Reduced levels of MCT3 in response to trauma or disease could contribute to pathologic changes in the retina2,3. MCT3 can form a heteromeric complex with the accessory protein CD147, an immunoglobulin superfamily protein.

ID gène: 65200

UniProt: O70461