NEO1 anticorps (Extracellular, N-Term)

N° du produit ABIN7885155

Cet anticorps Lapin Polyclonal détecte spécifiquement NEO1 dans WB, IHC, FACS et LCI. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour NEO1 anticorps (Extracellular, N-Term) (ABIN7885155)

Antigène: NEO1 (Neogenin 1 (NEO1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEO1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-NEO1 anticorps

Épitope: AA 701-715, Extracellular, N-Term

Fonction: A Rabbit Polyclonal antibody to Neogenin (extracellular)

Homologie: Human,rat - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KIRYRKASRKSDVTE, corresponding to amino acid residues 701 - 715 of mouse Neogenin

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235994)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur NEO1

Antigène: NEO1 (Neogenin 1 (NEO1))

Autre désignation: Neogenin 1

Sujet:

Synonyms: Neogenin 1, NEO1, NGN

Description: Neogenin also known as NEO1 is a member of the immunoglobulin (Ig) superfamily. It has been reported to be involved in diverse physiology and pathology functions, including cell proliferation, differentiation and migration1. Neogenin was originally isolated from embryonic chicken cerebellum and reported to be homologous to the axon guidance receptor deleted in colorectal cancer (DCC)2.Neogenin consists of 4 N-terminal Ig-like domains, followed by 6 fibronectin type III-like domains, a single transmembrane helix, and an intracellular domain. Neogenin is capable to mediate attractive and repulsive axon guidance depending on the ligand identity. Two main ligands of neogenin are Netrin-1 (NET1) and repulsive guidance molecules (RGMs)3.Interaction of Neogenin with RGMs leads to cytoskeleton rearrangements via Rho GTPases, this results in growth cone collapse. In contrast interaction with Netrin-1 triggers attractive growth cone response3. Recently it was shown that Neogenin plays a role in the maintenance of iron homeostasis via interaction with HJV (members of the RGM family)4.

ID gène: 18007

UniProt: P97798

Pathways: Transition Metal Ion Homeostasis, Regulation of Muscle Cell Differentiation, Tube Formation