Neurexin 1 anticorps (Extracellular, N-Term)

N° du produit ABIN7885166

Cet anticorps anti-Neurexin 1 Polyclonal Lapin (ABIN7885166) détecte spécifiquement Neurexin 1 dans WB, IF, IC et LCI. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Neurexin 1 anticorps (Extracellular, N-Term) (ABIN7885166)

Antigène: Neurexin 1 (NRXN1)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neurexin 1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Neurexin 1 anticorps

Épitope: AA 546-560, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Neurexin 1α

Homologie: Mouse,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KPRHQKDAKHPQMIK, corresponding to amino acid residues 546-560 of rat Nrxn1alpha

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:400

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236037)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Neurexin 1

Antigène: Neurexin 1 (NRXN1)

Autre désignation: Nrxn1

Sujet:

Synonyms: Nrxn1, Neurexin I-alpha

Description: Neurexins (NRXNs) are a family of transmembrane, synaptic adhesion molecules. NRXNS were identified as receptors for α-latrotoxin, a presynaptic toxin that triggers massive neurotransmitter release1. Neurexins are largely presynaptic proteins that form a trans-synaptic cell-adhesion complex with postsynaptic neuroligins2. They are encoded by three genes (NRXN1, NRXN2 and NRXN3), each using an upstream promoter to produce the longer α-isoform (α-NRXNs) and a downstream promoter to generate a shorter β-isoform (β- NRXNs).The α- and β-isoforms of each neurexin are single-pass transmembrane proteins maintaining identical transmembrane and intracellular domains but having distinct extracellular domains. NRXNs in neurons localize to the presynaptic membrane and bind trans-synaptically to postsynaptic adhesion molecules and receptors3. Neurexins are expressed in all neurons, and are subject to extensive alternative splicing, generating >1,000 splice variants, some of which exhibit highly regulated developmental and spatial expression patterns4. The extracellular domain of neurexin 1α (NRXN1α) is composed of three neurexin repeats (I, II, and III), which each contains the modules LNS-EGF-LNS. NRXN1α binds endogenous ligands including neuroligins, LRRTM family members, neurexophilin, α-dystroglycan, and GABA(A) receptors.NRXN1α gene mutations have been identified in neuropsychiatric diseases including Schizophrenia and Autism Spectrum Disorder5.

ID gène: 60391

UniProt: Q63372

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development