Neuroligin 2 anticorps (Extracellular, N-Term)

N° du produit ABIN7885170

Cet anticorps Lapin Polyclonal détecte spécifiquement Neuroligin 2 dans WB, IHC, IF, IC et LCI. Il présente une réactivité avec des échantillons de Rat et Souris.

Aperçu rapide pour Neuroligin 2 anticorps (Extracellular, N-Term) (ABIN7885170)

Antigène: Neuroligin 2 (NLGN2)

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neuroligin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Neuroligin 2 anticorps

Épitope: AA 657-670, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Neuroligin 2

Homologie: Mouse - identical, human - 12,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DLGPRAYDRFPGDS, corresponding to amino acid residues 657-670 of rat NLGN2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:400

FC: The optimal concentration should be determined by the user

ICC: 1:25

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236052)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Neuroligin 2

Antigène: Neuroligin 2 (NLGN2)

Autre désignation: NLGN2

Sujet:

Synonyms: NLGN2, NL2

Description: Neuroligins (NLGNs) are a family of postsynaptic cell adhesion molecules that play an important role in synaptic development and function1. Four genes encode for the different members of the neuroligin family in mammals: NLGN 1-4, which are differentially enriched in postsynaptic specializations of synapses2. Neuroligin 2 (NLGN2) is expressed in neurons in the brain and also in pancreatic β cells where it facilitates insulin secretion3.Synaptic maturation is promoted by the binding of Neuroligin 2 with presynaptic Neurexins, and these interactions are restricted to particular combinations of isoforms of the binding partners3. NLGN2 plays a role in synapse function and synaptic signal transmission, especially via γ-aminobutyric acid receptors (GABA(A) receptors). NLGN2 modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing4.Recent studied identified a loss-of-function mutation of NLGN2 in schizophrenia patients, suggesting an indispensable role of NLGN2 in regulating GABAergic functions5.

ID gène: 117096

UniProt: Q62888

Pathways: Cell-Cell Junction Organization, Synaptic Membrane