NPTXR anticorps (C-Term, Extracellular)

N° du produit ABIN7885179

Cet anticorps Lapin Polyclonal détecte spécifiquement NPTXR dans WB, IHC, FACS et LCI. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour NPTXR anticorps (C-Term, Extracellular) (ABIN7885179)

Antigène: NPTXR (Neuronal Pentraxin Receptor (NPTXR))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPTXR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-NPTXR anticorps

Épitope: AA 162-176, C-Term, Extracellular

Fonction: A Rabbit Polyclonal Antibody to NPTXR (extracellular)

Homologie: Rat - identical, human - 14 out of 15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RGLQDAGPRRDTMAD, corresponding to amino acid residues 162 - 176 of mouse NPTXR 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:400

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:1200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236082)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur NPTXR

Antigène: NPTXR (Neuronal Pentraxin Receptor (NPTXR))

Autre désignation: NPR

Sujet:

Synonyms: NPR, NPTXR

Description: Neuronal Pentraxin Receptor (NPTXR) belongs to the Pentraxin superfamily of proteins (NP) that is characterized by a pentraxin domain at the C-terminal end. It is the only pentraxin family member anchored to the cell membrane by a putative N-terminal transmembrane domain, as opposed to the other two family members, Neuronal Pentraxin1 (NP1) and Neuronal Pentraxin 2 (NP2) that are secreted proteins. NPs can form homo pentamers and hetero pentamers via their pentraxin domains 1.NPTXR was first identified as the receptor for the snake venom toxin taipoxin and was later found to bind to AMPARs at excitatory synapses and play important, roles in the activity-dependent regulation of neural circuits via this binding activity 1.Lately, the levels of NPTXR protein in cerebrospinal fluid has been identified as a novel potential biomarker of Alzheimer's disease progression and could have important utility in assessing treatment success in clinical trials 2. In addition, NPTXR was identified as a molecule required for gastric cancer metastasis 3.

ID gène: 73340

UniProt: Q99J85