NRP2 anticorps (Extracellular, N-Term)

N° du produit ABIN7885192

L’anticorps anti-NRP2 Polyclonal Lapin est utilisé pour la détection de NRP2 dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, IHC, IF et FACS.

Aperçu rapide pour NRP2 anticorps (Extracellular, N-Term) (ABIN7885192)

Antigène: NRP2 (Neuropilin 2 (NRP2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NRP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Détail du produit anti-NRP2 anticorps

Épitope: AA 747-758, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Neuropilin-2

Homologie: Rat,mouse - 11,12 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)REDQGGEWKHGR, corresponding to amino acid residues 747-758 of human neuropilin-2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 1:15

ICC: The optimal concentration should be determined by the user

IHC: 1:400

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236118)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur NRP2

Antigène: NRP2 (Neuropilin 2 (NRP2))

Autre désignation: Vascular endothelial cell growth factor 165 receptor 2

Sujet:

Synonyms: Vascular endothelial cell growth factor 165 receptor 2, VEGF165R2

Description: The neuropilins (NRPs) are single-pass multifunctional transmembrane glycoproteins that play an important role in cell development, immunity and cancer, and physiological and pathological angiogenesis. They were first discovered as regulators of nervous system development, acting as semaphorin co-receptors with plexins, as well as enhancers of cellular responses to members of the vascular endothelial growth factor (VEGF) family.The NRP family comprises two members: Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2), which are usually expressed as homodimers but can also appear as heterodimers. NRP2 contains a large extracellular N-terminal which consists of five domains, a short transmembrane domain and a small cytoplasmic domain1-3. NRP2 is expressed in a wide variety of cells including endothelial cells, neurons, pancreatic islet cells, hepatocytes, melanocytes and osteoblasts. NRP2 has been shown to mediate proliferation, survival, and migration of tumor cells3.NRP2 knockout mice studies show that mice are viable without defects in blood vessels but display abnormal lymphatic development and defects of the central and peripheral nervous systems2.

ID gène: 8828

UniProt: O60462

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals