NTSR2 anticorps (C-Term, Intracellular)

N° du produit ABIN7885195

L’anticorps anti-NTSR2 Polyclonal Lapin est utilisé pour la détection de NTSR2 dans des échantillons de Souris et Rat. Il a été validé pour WB, IHC, IF et IC.

Aperçu rapide pour NTSR2 anticorps (C-Term, Intracellular) (ABIN7885195)

Antigène: NTSR2 (Neurotensin Receptor 2 (NTSR2))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NTSR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Classe de qualité: Carrier-free

Détail du produit anti-NTSR2 anticorps

Épitope: AA 377-392, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Neurotensin Receptor 2

Homologie: Mouse - 14,16 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: CGEQHSLVPLPQEAPE, corresponding to amino acid residues 377-392 of rat NTSR2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: 1:200

IHC: 1:50-1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236129)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur NTSR2

Antigène: NTSR2 (Neurotensin Receptor 2 (NTSR2))

Autre désignation: NTR2

Sujet:

Synonyms: NTR2, NTSR2, Levocabastine-sensitive neurotensin receptor

Description: Neurotensin receptor 2 (NTR2) is one of three receptors that mediate the effects of the tridecapeptide neurotensin. Neurotensin is synthesized and secreted from neurons in the central neural system (CNS) and from endocrine cells in the gastrointestinal tract.NTR2 and NTR1 belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily while the third neurotensin receptor NTR3 (also called Sortilin) is a type I membrane protein with a large extracellular domain. Both NTR1 and NTR3 bind neurotensin with high affinity while NTR2 binds it with low affinity.1NTR2 signals preferentially through Gaq, resulting in the activation phopholipase C and intracellular Ca2+mobilization. However, the exact signaling mechanisms subsequent to NTR2 activation appear to depend on the species and on the cellular system in which the receptor is studied.NTR2 is expressed mainly in the central nervous system and dorsal root ganglion (DRG) neurons but has been also observed in peripheral tissues such as gastric parietal cells where it probably mediates the neurotensin-induced effects on gastric acid secretion.2The most established physiological role of NTR2 is its role in pain transmission as NTR2-defficient mice showed that NTR2 is the likely mediator of the neurotensin-induced analgesic responses.3

ID gène: 64636

UniProt: Q63384