Oxytocin Receptor anticorps (C-Term, Intracellular)

N° du produit ABIN7885219

L’anticorps anti-Oxytocin Receptor Polyclonal Lapin est utilisé pour la détection de Oxytocin Receptor dans des échantillons de Souris et Rat. Il a été validé pour WB, IHC et IF.

Aperçu rapide pour Oxytocin Receptor anticorps (C-Term, Intracellular) (ABIN7885219)

Antigène: Oxytocin Receptor (OXTR)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Oxytocin Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Classe de qualité: Carrier-free, KO Validated

Détail du produit anti-Oxytocin Receptor anticorps

Épitope: AA 346-358, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Oxytocin Receptor

Homologie: Mouse - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: CSARYLKGSRPGE, corresponding to amino acid residues 346-358 of rat Oxtr

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236202)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Oxytocin Receptor

Antigène: Oxytocin Receptor (OXTR)

Autre désignation: OXTR

Sujet:

Synonyms: OXTR, OT-R, OTR1

Description: Oxytocin receptor belongs to the class 1 family of G-protein coupled receptors (GPCR) and its role is to regulate reproductive physiology, social and emotional behaviors. Like other members belonging to the GPCR superfamily, it has seven transmembrane domains, extracellular N-terminus and intracellular C-terminal tail1,2.The Oxytocin receptor ligand oxytocin, is a peptide that functions both as a hormone and as a neurotransmitter, and plays an important role in social behavior, estrous cycle, induction of labor and milk ejection, anxiety-related behaviors, food intake, stress-related responses, and pain control. Activation of the receptor leads to the stimulation of phospholipase C by interacting with Gαq/11 in response to ligand binding1.Oxytocin receptor is widely abundant in several brain regions including the basal ganglia, the limbic system, the thalamus, the hypothalamus, the brainstem, and the spinal cord. It is also detected in the uterus, mammary gland, ovary, testis, prostate and kidney.Several studies have suggested that administration of oxytocin in humans has the ability to increase generosity, trust and eye gaze. Oxytocin levels in the plasma relates to parent-child bonding behaviors, feelings of romantic love, trust and empathy. Similarly, Oxytocin receptor knockout mice shows several abnormalities in social and emotional behavior such as increased aggression and deficits in nurturing, positive affection, attachment, sensitivity and social memory2,3.

ID gène: 25342

UniProt: P70536

Pathways: Myometrial Relaxation and Contraction, Feeding Behaviour