Periaxin anticorps (Intracellular, N-Term)

N° du produit ABIN7885226

Cet anticorps anti-Periaxin Polyclonal Lapin (ABIN7885226) détecte spécifiquement Periaxin dans WB, IF et IHC. L’anticorps est réactif avec des échantillons de Souris, Humain et Rat.

Aperçu rapide pour Periaxin anticorps (Intracellular, N-Term) (ABIN7885226)

Antigène: Periaxin (PRX)

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Periaxin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Détail du produit anti-Periaxin anticorps

Épitope: AA 155-170, Intracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Periaxin

Homologie: Mouse,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DVEFSFPKFSRLRR, corresponding to amino acid residues 155-170 of rat PRX

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:600

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:600

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236245)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Periaxin

Antigène: Periaxin (PRX)

Autre désignation: PRX

Sujet:

Synonyms: PRX, CMT4F

Description: Periaxin protein is a membrane-associated protein expressed in myelinating Schwann cells. It is required for the stable maintenance and development of a normal myelin sheath in the peripheral nervous system. It is also a member of cytoskeletal complexes in lens fibers where it plays an important role in maturation, packing, and membrane organization of lens fiber cell1,2. The periaxin gene (PRX) encodes two protein isoforms, L-periaxin and S-periaxin generated by alternative mRNA splicing. These proteins contain N-terminal PDZ domains (PSD-95/Discs-large/ZO-1) important for organizing protein-protein interactions.L-periaxin is a component of the dystroglycan-dystrophin-related protein-2 complex (DRP2) linking the Schwann cell cytoskeleton to the extracellular matrix. Its location changes during myelination, at first the protein is localized to the adaxonal plasma membrane and later, in the abaxonal plasma membrane. S-periaxin is distributed in a uniform manner in the cytoplasm and the nucleus of the Schwann cell1-3. Mutations in the Periaxin gene are known to cause autosomal recessive demyelinating in Type 4F Charcot-Marie-Tooth (CMT4F) and Dejerine-Sottas disease3.Periaxin knockout mice develop normally myelinated peripheral nervous system at first but develop a late onset demyelinating peripheral neuropathy1.

ID gène: 78960

UniProt: Q63425