Plexin A2 anticorps (Extracellular, N-Term)

N° du produit ABIN7885233

Cet anticorps Lapin Polyclonal détecte spécifiquement Plexin A2 dans WB, IHC, FACS, IF et LCI. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Plexin A2 anticorps (Extracellular, N-Term) (ABIN7885233)

Antigène: Plexin A2 (Plxna2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Plexin A2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Plexin A2 anticorps

Épitope: AA 205-218, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Plexin-A2

Homologie: Rat,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RDPESSAMLDYELH, corresponding to amino acid residues 205-218 of mouse PLXNA2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:400

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236264)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Plexin A2

Antigène: Plexin A2 (Plxna2)

Autre désignation: PLXNA2

Sujet:

Synonyms: PLXNA2, PLXN2, Semaphorin receptor OCT

Description: The Plexin gene family is comprised of at least 9 members in 4 subfamilies. Plexins are widely expressed in neurons but have been also detected in epithelial cells1. Plexins closely interact with a large family of proteins called Semaphorins which control a variety of processes in the CNS including cell migration and axonal growth. Plexins and Semaphorins share a common feature of a conserved 500 amino acid "sema" domain2. The ectodomain of PLXNA2 is an N-terminal seven bladed β-propeller sema domain followed by a cysteine rich PSI (plexin-semaphorin-integrin) domain. PLXNA2 has four N-terminal domains and unlike semaphorins the sema domain of unliganded PLXNA2 does not homodimerize readily.Many of the functions of Class 3 semaphorins (Sema3A-Sema3G) are mediated by Plexin-A2 (PLXNA) and other A-plexins. Sema3 signaling depends on semaphorin interacting with one of the two Nrp co-receptors that associate with PLXNA to generate holoreceptors.PLXNA also interacts with semaphorin 6A (Sema6A). Before binding, the Sema6A ectodomain can be found in a 'face-to-face' homodimer arrangement, similar to the arrangement in Sema3, whereas PLXNA is in an unexpected 'head-on' homodimer arrangement. The structure of the Sema6A-PLXNA signaling complex is a 2:2 heterotetramer3.In prostate cancer TMPRSS:ERG gene fusion causes aberrant expression of the transcription factor ERG and the induction of cell migration and invasion. TMPRSS:ERG upregulates PLXNA expression and elevated PLXNA levels were found in prostate cancer cells. Levels of PLXNA were even higher in metastatic prostate cancer than in localized tumors suggesting PLXNA may play a role in the disease's development.

ID gène: 18845

UniProt: P70207