Plexin A4 anticorps (Extracellular, N-Term)

N° du produit ABIN7885235

Cet anticorps anti-Plexin A4 Polyclonal Lapin (ABIN7885235) détecte spécifiquement Plexin A4 dans WB, IHC, FACS et LCI. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Plexin A4 anticorps (Extracellular, N-Term) (ABIN7885235)

Antigène: Plexin A4 (PLXNA4)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Plexin A4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Plexin A4 anticorps

Épitope: AA 201-215, Extracellular, N-Term

Fonction: A Rabbit Polyclonal antibody to Plexin-A4 (extracellular)

Homologie: Human,Rat - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RKLTKNSEADGMFAY, corresponding to amino acid residues 201 - 215 of mouse Plexin-A4

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Plexin A4

Antigène: Plexin A4 (PLXNA4)

Autre désignation: PLXNA4

Sujet:

Synonyms: PLXNA4

Description: The plexin family are transmembrane proteins which are classified into four subfamilies: plexin -A, B, C and D. The plexins serve as a receptor for seamaphorins (Sema), axon guidance molecules involved in cellular processes such as axon pruning and repulsion, regulation of cell migration, vascular remodeling and more1. All family members consist of a Sema domain at the N-terminus responsible for Sema binding. In addition, plexins have PSI and IPT (Integrin, Plexin, and Transcription factor) domains, which connect to the transmembrane (TM) helix. Moreover, intracellular region of all plexins contains a membrane proximal juxtamembrane region (JM), a Rho GTPase-binding domain (RBD), and GTPase Activating Protein (GAP) domain2.Plexin-A4 acts as a receptor for the secreted semaphorins Sema3A and Sema6A in the central nervous system, and mediates axon repulsion and synaptic plasticity. Moreover, genome-wide significant association study (GWAS) on humans, has identified that several single nucleotide polymorphisms (SNPs) in PLXNA4 can increase the risk of Alzheimer's disease (AD) 3,4.In the immune system, Plexin-A4 has been implicated in macrophage Toll-like receptor (TLR)-mediated signaling in sepsis, negative regulation of T-cell mediated immune responses in cancer5.

ID gène: 243743

UniProt: Q80UG2

Pathways: Regulation of Cell Size