Plexin C1 anticorps (Extracellular, N-Term)

N° du produit ABIN7885238

Cet anticorps anti-Plexin C1 Polyclonal Lapin (ABIN7885238) détecte spécifiquement Plexin C1 dans WB, IHC, FACS et LCI. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Plexin C1 anticorps (Extracellular, N-Term) (ABIN7885238)

Antigène: Plexin C1 (PLXNC1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Plexin C1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Plexin C1 anticorps

Épitope: AA 860-874, Extracellular, N-Term

Fonction: A Rabbit Polyclonal antibody to Plexin-C1 (extracellular)

Homologie: Mouse - identical Rat - 14 out of 15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)EVKIQKENDNFNISK, corresponding to amino acid residues 860 - 874 of human Plexin-C1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236272)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Plexin C1

Antigène: Plexin C1 (PLXNC1)

Autre désignation: Virus-Encoded Semaphorin Protein Receptor, VESPR

Sujet:

Synonyms: Virus-Encoded Semaphorin Protein Receptor, VESPR, CD232, PLXNC1

Description: Plexin-C1 also known as Virus-encoded semaphorin protein receptor, is a ~210 kDa type I transmembrane receptor that regulates cytoskeletal remodeling and adhesion in human melanocytes.It belongs to the family of Plexin receptors, these are type I transmembrane proteins (A-D) that share a highly conserved cytoplasmic domain and an intracellular region containing an intrinsic Ras-GTPase activating (GAP) domain. Plexin receptors bind semaphorins: a class of secreted and membrane proteins 1. The natural ligand of Plexin C1 is Semaphorin -7A (#ASR-077).Plexin-C1 is highly expressed in melanocytes, neurons, neutrophils, dendritic cells and pre-osteoblasts and it has a complex effect on migration of melanocytes and melanoma, that depends on the phase of progression of this type of cancer 2,3. It also has additional roles in the partitioning of paraventricular and supraoptic neurons in the hypothalamus, in the development of inflamation and in inhibition of neutrophils phagocytosis 3,4.

ID gène: 10154

UniProt: O60486