Prostacyclin Receptor anticorps (3rd Extracellular Loop)

N° du produit ABIN7885324

L’anticorps anti-Prostacyclin Receptor Polyclonal Lapin est utilisé pour la détection de Prostacyclin Receptor dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, FACS et LCI.

Aperçu rapide pour Prostacyclin Receptor anticorps (3rd Extracellular Loop) (ABIN7885324)

Antigène: Prostacyclin Receptor (PTGIR)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Prostacyclin Receptor est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Prostacyclin Receptor anticorps

Épitope: 3rd Extracellular Loop, AA 290-302

Fonction: A Rabbit Polyclonal Antibody to Prostacyclin Receptor (PTGIR)

Homologie: Mouse - identical, human - 11,13 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)TQAIAPDSREMGD, corresponding to amino acid residues 290-302 of rat PTGIR

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236620)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Prostacyclin Receptor

Antigène: Prostacyclin Receptor (PTGIR)

Autre désignation: Prostanoid IP receptor

Sujet:

Synonyms: Prostanoid IP receptor, Prostaglandin I2 receptor, PGI2 receptor

Description: Prostaglandins comprise a family of locally acting hormones, whose synthesis is initiated by the enzyme COX. This pathway is involved in a broad variety of pathological conditions such as cancer, inflammation and hypertension.Prostaglandin I2 receptor (PGI2 receptor) is G-coupled protein receptor (GPCR) with seven hydrophobic transmembrane segments and an extracellular NH2 terminus. Prostaglandin receptors belong to family A, group V of GPCRs. There is significant ligand-binding cross-reactivity between different prostaglandins and different receptors in the family. Within the PG family, receptors share roughly 20-30 % of their sequence and there are 34 identical residues across the family. Twenty of these residues are unique to PG receptors and are not shared by other GPCRs. The unique residues reside mostly in the transmembrane region and in the second extracellular loop region. Both of these regions are implicated in ligand binding. The PGI2 receptor signals primarily via stimulation of cAMP generation but through PIP2 as well despite a much higher agonist concentration required for PIP2 hydrolysis.PGI2 receptor mRNA is highly expressed in the human heart, aorta, kidney, liver and lung tissues and in mice thymus, heart and spleen1. Mice lacking PGI2 receptor have been shown to have a reduced inflammation response and a significant decrease in clinical arthritis. In addition, human patients with a dysfunctional PGI2 receptor variant exhibit an enhanced atherothrombotic phenotype with higher incidence of triple vessel coronary disease and cardiovascular events2.

ID gène: 292661

UniProt: P43253

Pathways: cAMP Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling