Sodium Channel-Pan (AA 1501-1518), (Intracellular Loop) anticorps

N° du produit ABIN7885404

Cet anticorps Lapin Polyclonal détecte spécifiquement Sodium Channel-Pan dans IF, IHC, WB, IC et IP. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Sodium Channel-Pan (AA 1501-1518), (Intracellular Loop) anticorps (ABIN7885404)

Antigène: Sodium Channel-Pan

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB), Immunochromatography (IC), Immunoprecipitation (IP)

Classe de qualité: Carrier-free

Détail du produit

Épitope: AA 1501-1518, Intracellular Loop

Fonction: A Rabbit Polyclonal Antibody to Pan NaV Channel

Homologie: The epitope is identical in all isoforms of NaV1 in all vertebrates,and highly homologous in molluscan,insect voltage-gated Na+ channels

Purification: Affinity purified on immobilized antigen.

Immunogène: TEEQKKYYNAMKKLGSKK(C), corresponding to amino acid residues 1501-1518 of rat NaV1.1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détail du antigène

Antigène: Sodium Channel-Pan

Autre désignation: Pan sodium channel

Sujet:

Synonyms: Pan sodium channel, SP19

Description: Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit.6,7

ID gène: 81574

UniProt: P04774