S1PR2 anticorps (2nd Cytoplasmic Loop)

N° du produit ABIN7885537

L’anticorps anti-S1PR2 Polyclonal Lapin est utilisé pour la détection de S1PR2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et IHC.

Aperçu rapide pour S1PR2 anticorps (2nd Cytoplasmic Loop) (ABIN7885537)

Antigène: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S1PR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Détail du produit anti-S1PR2 anticorps

Épitope: 2nd Cytoplasmic Loop, AA 129-146

Fonction: A Rabbit Polyclonal Antibody to Sphingosine 1-Phosphate Receptor 2

Homologie: Rat - 17,18 amino acid residues identical, human - 16

Purification: Affinity purified on immobilized antigen.

Immunogène: ERQVALAKVKLYGSDKSC, corresponding to amino acid residues 129-146 of mouse S1PR2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237271)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur S1PR2

Antigène: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Autre désignation: Sphingosine 1-phosphate receptor 2

Sujet:

Synonyms: Sphingosine 1-phosphate receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Lysophospholipid receptor B2, LPB2

Description: Lysophospholipids constitute a group of important lipid mediators, lysophosphatidic acid (LPA) a glycerolysophospholipid and sphingosine 1-phosphate (S1P), a lysosphingolipid. Sphingosine 1-phosphate is a bioactive lipid derived from metabolism of sphingomyelin1. Sphingosine 1-phosphate is implicated in the regulation of many cellular functions including proliferation, apoptosis, survival, adhesion, differentiation, and migration2.Sphingosine 1-phosphate exerts its activity through five distinct G-protein-coupled receptors, (also named endothelial differentiation gene receptors - EDG), S1PR1 (EDG-1), S1PR2 (EDG-5), S1PR3 (EDG-3), S1PR4 (EDG-6), and S1PR5 (EDG-8)3.Sphingosine 1-phosphate receptor 2 (S1PR2) is ubiquitously expressed. S1PR2 mRNA was detected in the brain, heart, spleen, liver, lung, thymus, kidney and skeletal muscle4. Unlike S1PR1, knockout of SIPR2 gene is not lethal5.

ID gène: 14739

UniProt: P52592

Pathways: Synaptic Membrane