STOML1 anticorps (Extracellular, N-Term)

N° du produit ABIN7885541

Cet anticorps anti-STOML1 Polyclonal Lapin (ABIN7885541) détecte spécifiquement STOML1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour STOML1 anticorps (Extracellular, N-Term) (ABIN7885541)

Antigène: STOML1 (Stomatin (EPB72)-Like 1 (STOML1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STOML1 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-STOML1 anticorps

Épitope: AA 4-17, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Stomatin-Like Protein 1

Homologie: Rat,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RSGYRALPLGDFDR, corresponding to amino acid residues 4-17 of mouse STOML1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:500-1:800

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237284)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur STOML1

Antigène: STOML1 (Stomatin (EPB72)-Like 1 (STOML1))

Autre désignation: STOML1

Sujet:

Synonyms: STOML1, SLP-1, STORP, Slipin-1, hUNC-24

Description: The Stomatin-like protein family contains five members and are characterized by the presence of a structurally conserved core called the stomatin-domain. This stomatin-domain is further related to a domain found in members of the prohibitin, flotillin and HflK/HflC protein families and has accordingly also been called the SPFH domain.All mammalian stomatin proteins are integral membrane protein with a single, relatively short, hydrophobic membrane insertion domain, followed by the core stomatin-domain. A single conserved proline residue (known to be a potent helix breaker) in the hydrophobic region is required for the formation of the protein's hairpin structure. The N-terminal domain is extracellular. Stomatin-like protein 1 (STOML1) has a typical stomatin-domain at the N-terminus and an additional sterol carrier protein-2 (SCP-2) domain at the C-terminus. STOML-1 is targeted to the late endosomal compartment where it interacts with stomatin. STOML-1 is predominantly expressed in the brain, in a subpopulation of sensory neurons in the dorsal root ganglia. Much lower levels are detected in other tissues1.Following anoxia, STOML-1 expression is up-regulated by the oxidative response factor SKN-1/Nrf. SKN-1/Nrf is required for both rapid mitochondrial refusion and rapid behavioral recovery during reoxygenation suggesting that STOML-1 helps facilitate mitochondrial dynamics following anoxia2.STOML-1 also modulates the proton-sensitive members of the acid-sensing ion channel (ASIC) family. STOML-1 strongly inhibits ASIC1a and accelerates the inactivation time constant of ASIC3, but has no effect on the splice variant ASIC1b3.

ID gène: 69106

UniProt: Q8CI66