SUCNR1 anticorps (3rd Extracellular Loop)

N° du produit ABIN7885545

Cet anticorps Lapin Polyclonal détecte spécifiquement SUCNR1 dans WB, IHC, FACS et LCI. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour SUCNR1 anticorps (3rd Extracellular Loop) (ABIN7885545)

Antigène: SUCNR1 (Succinate Receptor 1 (SUCNR1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUCNR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-SUCNR1 anticorps

Épitope: 3rd Extracellular Loop, AA 248-262

Fonction: A Rabbit Polyclonal Antibody to Succinate Receptor 1

Homologie: 15 amino acid residues identical,Mouse - 14, human - 12

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RNVRIASRLDSWPQG, corresponding to amino acid residues 248-262 of rat GPR91/Succinate Receptor 1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 mg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237300)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur SUCNR1

Antigène: SUCNR1 (Succinate Receptor 1 (SUCNR1))

Autre désignation: G-protein coupled receptor 91

Sujet:

Synonyms: G-protein coupled receptor 91, Succinate receptor 1

Description: GPR91 (Succinate Receptor 1), a member of the GPCR superfamily, is specifically activated by extracellular succinate outside the tricarboxylic acid cycle, resulting in activation of paracrine and endocrine effectors. Activation of GPR91 is associated with several diseases, including hypertension and diabetes1,2.GPR91 was shown to regulate normal retinal vascularization, proliferative ischemic retinopathy and cortical revascularization post-ischemia. Activation of GPR91 influences different tissues such as kidney, heart, retina, white adipose tissue, and liver.Through the activation of GPR91, succinate affects motility, migration, and growth of dendritic cells. In addition, the receptor directly promotes chemotaxis and potentiates activation initiated by Toll-like receptor agonists in dendritic cells1-3.In the heart GPR91 mediates succinate-induced cardiomyocyte death. It was demonstrated that upholding levels of serum succinate can cause cardiac hypertrophy through the activation of the GPR911,2.

ID gène: 408199

UniProt: Q6IYF9