SYNDIG1 anticorps (Intracellular, N-Term)

N° du produit ABIN7885546

L’anticorps anti-SYNDIG1 Polyclonal Lapin est utilisé pour la détection de SYNDIG1 dans des échantillons de Souris, Rat et Humain. Il a été validé pour WB.

Aperçu rapide pour SYNDIG1 anticorps (Intracellular, N-Term) (ABIN7885546)

Antigène: SYNDIG1 (Synapse Differentiation Inducing 1 (SYNDIG1))

Reactivité: Souris, Rat, Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYNDIG1 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-SYNDIG1 anticorps

Épitope: AA 119-132, Intracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to SynDIG1

Homologie: Mouse,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RSPTKDSLEYPDGK, corresponding to amino acid residues 119-132 of rat SynDIG1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237303)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur SYNDIG1

Antigène: SYNDIG1 (Synapse Differentiation Inducing 1 (SYNDIG1))

Autre désignation: Synapse differentiation-inducing gene protein 1

Sujet:

Synonyms: Synapse differentiation-inducing gene protein 1, Transmembrane Protein 90B, TMEM90B, Dispanin subfamily C member 2, DSPC2

Description: SynDIG1 (Synapse differentiation induced gene 1) is a brain-specific, highly conserved type II integral membrane protein detected at excitatory synapses. The protein is responsible for the regulation of excitatory synapse number and strength in hippocampal neurons. The protein plays an important role during synapse development in regulating AMPA receptor (AMPAR) and PSD-95 content at excitatory synapses1,2.SynDIG family includes four members: SynDIG1-4. SynDIG1 structure includes a large intracellular N-terminal region followed by a single transmembrane domain and a second hydrophobic segment that does not span the membrane. The membrane-associated region forms a three-helical bundle with two cysteine residues located at positions 191 and 192 in the juxta-transmembrane region exposed to the cytoplasm1,2.In studies conducted on mice, deletion of endogenous SynDIG1 in the mouse brain results in a significant decrease in excitatory synapse maturation, but not in synapse composition. Thus, SynDIG1 is not required for synaptogenesis in vivo1. Contrarily, overexpression of SynDIG1 in cultures of dissociated rat hippocampal neurons shows a significant increase in excitatory synapse strength and number.

ID gène: 362235

UniProt: Q58DZ9

Pathways: Synaptic Membrane