TAUT anticorps (C-Term, Intracellular)

N° du produit ABIN7885569

Cet anticorps Lapin Polyclonal détecte spécifiquement TAUT dans WB. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour TAUT anticorps (C-Term, Intracellular) (ABIN7885569)

Antigène: TAUT (Taurine Transporter (TAUT))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAUT est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-TAUT anticorps

Épitope: AA 581-594, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Taurine Transporter (SLC6A6)

Homologie: Mouse,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)TPREPNRWAVEREG, corresponding to amino acid residues 581-594 of rat TauT

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur TAUT

Antigène: TAUT (Taurine Transporter (TAUT))

Autre désignation: Sodium- and chloride-dependent taurine transporter

Sujet:

Synonyms: Sodium- and chloride-dependent taurine transporter, TauT

Description: Taurine (2-aminoethane-sulfonice acid) is one of the most abundant amino acids found in the human body. It is involved in cell regulation and modulates the concentration of intracellular free calcium. It also plays a substantial role in many other functions varying from neurotransmission in the central nervous system to promotion of cell differentiation in the brain to cytoprotection against oxidative stress1.Taurine is not used for protein synthesis, and in addition to its uptake in nutrition, it can be synthesized in pancreatic mammalian cells by cysteine dioxygenase and sulfinoalanine decarboxylase enzymes2.Taurine is found mainly in organs such as the brain, retina and muscle tissue.The uptake of taurine is conducted through the taurine transporter (TauT). The energy for passage through the transporter is derived by Na+ and Cl- concentration similar to the uptake of other amino acids3. TauT also transports GABA, albeit with a lower affinity. The transporter has twelve transmembrane domains and intracellular N- and C-termini.TauT expression is regulated by cAMP which was found to increase its regulation in MDCK cells and also by PKC via means of post-translational modification. PKC activation leads to reduced taurine transport4. PKC is believed to phosphorylate the highly conserved serine-322 position in the transporter.Taurine deficiency is linked to cardiomyopathies in the hearts of cats and to a decrease in cardiac muscle sensitivity to calcium5 and better understanding of its transport may improve research of these diseases.

ID gène: 29464

UniProt: P31643