Tetraspanin 2 anticorps (Extracellular, Loop 2)

N° du produit ABIN7885571

Cet anticorps anti-Tetraspanin 2 Polyclonal Lapin (ABIN7885571) détecte spécifiquement Tetraspanin 2 dans WB, FACS, IHC et LCI. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Tetraspanin 2 anticorps (Extracellular, Loop 2) (ABIN7885571)

Antigène: Tetraspanin 2 (TSPAN2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tetraspanin 2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Tetraspanin 2 anticorps

Épitope: AA 114-130, Extracellular, Loop 2

Fonction: A Rabbit Polyclonal antibody to Tetraspanin 2 (extracellular)

Homologie: Rat - identical,Human - 14 out of 17 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DVAIRHVQSMYEEAYSD, corresponding to amino acid residues 114 - 130 of mouse TSPAN2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Tetraspanin 2

Antigène: Tetraspanin 2 (TSPAN2)

Autre désignation: Tetraspan NET-3

Sujet:

Synonyms: Tetraspan NET-3, TSPAN2

Description: Tetraspanin 2 (TSPAN2) is a member of the Tetraspanin family of proteins, that comprises 33 members in humans. The family is characterized by the presence of four transmembrane domains, which give rise to the name "tetraspanin", as well as the presence two extracellular loops (EC1 and EC2), a small cytoplasmic loop, and short N- and C-terminal tails 1,2.Tetraspanins are able to interact with each other and also with numerous partner proteins such as integrins, growth factor receptors and ion channels, to create a dynamic network of interactions known as the tetraspanin-enriched microdomains (TEMs). Consequently, tetraspanins are regarded as molecular organizers and by forming complexes with these proteins, tetraspanins can modulate signal transduction pathways and cellular responses 2,3,4.Although TSPAN2 shares a relatively high homology with well-studied tetraspanins like CD9 (TSPAN29) or CD81 (TSPAN28), it has been less well-characterised up until now 3.Nevertheless, TSPAN2, like the related CD9 and CD81 proteins, has been described in relation to exosome formation, specifically regarding neuroinflammation and microglia activation 5, as well as oligodendrocyte differentiation into myelin-forming glia and in the progression of tumor metastasis by modulating cancer cell motility and invasion 3,5.

ID gène: 70747

UniProt: Q922J6