TMC6 anticorps (Cytosolic, Intracellular)

N° du produit ABIN7885613

Cet anticorps anti-TMC6 Polyclonal Lapin (ABIN7885613) détecte spécifiquement TMC6 dans WB. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour TMC6 anticorps (Cytosolic, Intracellular) (ABIN7885613)

Antigène: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMC6 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-TMC6 anticorps

Épitope: AA 681-695, Cytosolic, Intracellular

Fonction: A Rabbit Polyclonal Antibody to TMC6 Channel

Homologie: Rat,mouse - 13,14 amino acid residues are identical

Purification: Affinity purified on immobilized antigen.

Immunogène: CGPFRTLDTMYEAGR, corresponding to amino acid residues 681-695 of human TMC6

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:800

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237513)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur TMC6

Antigène: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Autre désignation: Transmembrane channel-like protein 6

Sujet:

Synonyms: Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1, Protein LAK-4, LAK4P, EVIN1, EV1

Description: The EVER gene belongs to a larger family of proteins referred to as the transmembrane channel-like protein (TMC) family1. The EVER1/TMC6 integral membrane protein, is located in the endoplasmic reticulum (ER) of keratinocytes, where it forms a complex with zinc transporter-1 (ZnT-1), a membrane protein responsible for zinc efflux and resistance to zinc toxicity, and thereby controlling the cellular zinc balance2. The EVER1 protein is predicted to have 10 transmembrane domains and 2 leucine zipper motifs1.The EVER1 gene encodes 2 alternatively spliced proteins, one 805 amino acids long and the other 454 amino acids, in the same open reading frame. The EVER genes are thought to be transcribed in numerous tissues including the skin1. Mutations in the TMC6 are implicated in the development of the rare autosomal recessive disease Epidermodysplasia Verruciformis (EV)3. EV is characterized by extreme susceptibility to infection by cutaneous human papillomaviruses (HPV) of the beta genus. The TMC6 genes may be involved in controlling HPV gene expression and replication in epidermal keratinocytes or they may directly affect innate and adaptive immune responses which control the clearance of HPV-infected keratinocytes in EV cases4. A recent report indicated an association between genetic variation in the TMC6 region and development of cervical cancer (CxCa)5.

ID gène: 11322

UniProt: Q7Z403