TMEM119 anticorps (Extracellular, N-Term)

N° du produit ABIN7885617

Cet anticorps Lapin Polyclonal détecte spécifiquement TMEM119 dans FACS et WB. Il présente une réactivité avec des échantillons de Souris et Rat.

Aperçu rapide pour TMEM119 anticorps (Extracellular, N-Term) (ABIN7885617)

Antigène: TMEM119 (Transmembrane Protein 119 (TMEM119))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMEM119 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-TMEM119 anticorps

Épitope: AA 53-67, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to TMEM119 (extracellular)

Homologie: Rat - 12,15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)GTPAFSPTPERPQPT, corresponding to amino acid residues 53 - 67 of mouse TMEM119 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237517)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur TMEM119

Antigène: TMEM119 (Transmembrane Protein 119 (TMEM119))

Autre désignation: Transmembrane Protein 119

Sujet:

Synonyms: Transmembrane Protein 119, Osteoblast induction factor, OBIF

Description: Transmembrane protein 119, Tmem119, is a bone formation related factor that belongs to a group of bone morphogenetic proteins (BMPs). It is a class IA single pass transmembrane protein1.Tmem119 promotes the differentiation of myoblasts (embryonic precursors of muscle cells) into osteoblasts and plays a role in numerous BMP signaling pathways1,2.Tmem119 is uniquely expressed in microglia cells and it is therefore used as a microglia-specific homeostatic marker that can assist in differentiating microglia cells from peripherally derived macrophages in the brain3. This marker is very important for diagnosing CNS disease: monocytes/macrophages are key cellular modulators of brain homeostasis. In the healthy brain resident microglia are the predominant macrophage cell population but when the blood-brain barrier is leaking peripheral monocytes/macrophages can infiltrate the brain and participate in CNS disease pathogenesis. Distinguishing these two monocytesmacrophages populations is often challenging and hence the existence of a highly expressed and robust microglia marker such as Tmem119 is very important4.

ID gène: 231633

UniProt: Q8R138