CRTC2 anticorps (pSer171)

N° du produit ABIN745988

L’anticorps Lapin Polyclonal anti-CRTC2 a été validé pour WB, ELISA et FACS. Il convient pour détecter CRTC2 dans des échantillons de Humain et Souris. Il y a 4+ publications disponibles.

Aperçu rapide pour CRTC2 anticorps (pSer171) (ABIN745988)

Antigène: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRTC2 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-CRTC2 anticorps

Épitope: pSer171

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human CREB regulated transcription coactivator 2 around the phosphorylation site of Ser171

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-CRTC2 (ABIN745988)

Slocum, Skoko, Wakabayashi, Aja, Yamamoto, Kensler, Chartoumpekis: "Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet." dans: Archives of biochemistry and biophysics, Vol. 591, pp. 57-65, (2016) (PubMed).

Seok, Fu, Choi, Li, Zhu, Kumar, Sun, Yoon, Kang, Zhong, Ma, Kemper, Kemper: "Transcriptional regulation of autophagy by an FXR-CREB axis." dans: Nature, Vol. 516, Issue 7529, pp. 108-11, (2015) (PubMed).

Tian, Zhao, Sun, Zhi, Cheng, Zhou, Hu: "CRTC2 enhances HBV transcription and replication by inducing PGC1? expression." dans: Virology journal, Vol. 11, Issue 1, pp. 30, (2014) (PubMed).

Cicerchi, Li, Kratzer, Garcia, Roncal-Jimenez, Tanabe, Hunter, Rivard, Sautin, Gaucher, Johnson, Lanaspa: "Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 8, pp. 3339-50, (2014) (PubMed).

Détails sur CRTC2

Antigène: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Autre désignation: TORC2

Sujet:

Synonyms: TORC2, TORC-2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2, Transducer of CREB protein 2, CRTC2

Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

ID gène: 200186

UniProt: Q53ET0

Pathways: AMPK Signaling, Carbohydrate Homeostasis