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Smad1/5 anticorps (pSer463, pSer465) (Biotin)

SMAD1/5 Reactivité: Souris, Rat WB, ELISA, IHC (fro), IHC (p) Hôte: Lapin Polyclonal Biotin
N° du produit ABIN746035
  • Antigène Tous les produits Smad1/5 (SMAD1/5)
    Smad1/5 (SMAD1/5) (Smad1/5 Protein (SMAD1/5))
    Épitope
    • 16
    • 14
    • 14
    pSer463, pSer465
    Reactivité
    • 17
    • 15
    • 15
    Souris, Rat
    Hôte
    • 31
    Lapin
    Clonalité
    • 31
    Polyclonal
    Conjugué
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp Smad1/5 est conjugé à/à la Biotin
    Application
    • 26
    • 26
    • 15
    • 14
    • 5
    • 5
    • 5
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This phosphorylation site is homologous in the listed cross reactive species at the specified location.
     Réactivité croisée
    Souris, Rat
    Homologie
    Human
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic phosphopeptide derived from human Smad1/5 around the phosphorylation site of Ser463/465
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    Smad1/5 (SMAD1/5) (Smad1/5 Protein (SMAD1/5))
    Autre désignation
    Smad1/5 + (SMAD1/5 Produits)
    Sujet

    Synonyms: Smad1 phospho S463/465, Smad1 phospho Ser463/465, p-Smad1 Ser463/465, Mothers against decapentaplegic homolog 1, BSP 1, BSP1, BSP-1, Dwarfin A, DwfA, hSMAD 1, hSMAD1, JV 41, JV4 1, JV4-1, JV41, MAD mothers against decapentaplegic homolog 1, Mad related protein 1, MADH 1, MADH1, Madr 1, MADR1, Mothers against decapentaplegic homolog 1, Mothers against DPP homolog 1, Sma and Mad related protein 1, SMAD 1, SMAD-1, SMAD family member 1, SMAD mothers against DPP homolog 1 Drosophila, Spinal muscular atrophy distal with upper limb predominance, TGF beta signaling protein 1, Transforming growth factor beta signaling protein 1, SMAD1_HUMAN, MAD homolog 1, Mothers against DPP homolog 1, Mad-related protein 1, SMAD family member 1, Smad1, Transforming growth factor-beta-signaling protein 1.

    Background: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].

    ID gène
    4086, 4090
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