ING5 anticorps

N° du produit ABIN7938284

L’anticorps anti-ING5 Monoclonal Rat est utilisé pour la détection de ING5 dans des échantillons de Humain. Il a été validé pour WB et IP.

Aperçu rapide pour ING5 anticorps (ABIN7938284)

Antigène: ING5 (Inhibitor of Growth Family, Member 5 (ING5))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp ING5 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: 7A11

Détail du produit anti-ING5 anticorps

Fonction: ING5 antibody (mAb) (Clone 7A11)

Purification: Protein G Chromatography

Immunogène: This antibody was raised against full length recombinant human ING5 (Inhibitor of growth protein 5) protein.

Isotype: IgG2a

Information d'application

Indications d'application: WB: 0.5 - 2 μg/mL IP: 5 μg/mL This antibody is also available as an AbFlex engineered recombinant antibody. For details on the corresponding AbFlex Recombinant Antibody, see Catalog No. 91329.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur ING5

Antigène: ING5 (Inhibitor of Growth Family, Member 5 (ING5))

Autre désignation: ING5

Sujet:

Background_Plain: ING5 (Inhibitor of Growth 5) possesses different structural and functional elements, including a PHD (plant homeodomain), an NCR (novel conserved region), a LZL (leucine zipper like) finger, and two NLS (nuclear localization sequence) motifs. ING proteins bind to methylated core histones through their PHD motif, notably ING5 reads histone H3 when di- or trimethylated at lysine 4 (H3K4me2/3). ING5 is a subunit of two distinct histone acetyltransferase (HAT) complexes with HBO1 or MOZ/MORF as the two catalytic subunits. These complexes contain two different alternative scaffolding proteins, i.e. a BRPF protein or a JADE protein, that determine their specificity towards different core histones. ING complexes appear to participate in transcription, for example by interacting with transcriptional regulators such as the tumor suppressor p53 and through the ability of ING5 to recognize H3K4me3, a mark associated with open chromatin and transcribed genes.

Aliases: Inhibitor of growth protein 5, p28ING5

Poids moléculaire: 30 kDa

NCBI Accession: NP_001317091

Pathways: Chromatin Binding