NAT10 anticorps

N° du produit ABIN7938364

Cet anticorps Lapin Polyclonal détecte spécifiquement NAT10 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour NAT10 anticorps (ABIN7938364)

Antigène: NAT10 (N-Acetyltransferase 10 (GCN5-Related) (NAT10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NAT10 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NAT10 anticorps

Fonction: NAT10 antibody (pAb)

Purification: Protein A Chromatography

Immunogène: This antibody was raised against a human RNA cytidine acetyltransferase isoform a.

Isotype: IgG

Information d'application

Indications d'application: WB: 1 - 4 μg dilution

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG supplied in 62 mM Trisodium citrate, 87 mM Tris pH 7, 30 % glycerol, 0.035 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur NAT10

Antigène: NAT10 (N-Acetyltransferase 10 (GCN5-Related) (NAT10))

Autre désignation: NAT10

Sujet:

Background_Plain: NAT10 (N-Acetyltransferase 10) antibody is a RNA cytidine acetyltransferase that catalyzes the formation of N(4)- acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs and mediates the formation of ac4C at position 1842 in 18S rRNA. NAT10 requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. In addition to RNA acetyltransferase activity, NAT10 is also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro. It activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. NAT10 involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation.

Aliases: N-Acetyltransferase 10

Poids moléculaire: 130 kDa

NCBI Accession: NP_078938