SMC3 anticorps (acLys105, acLys106, C-Term)

N° du produit ABIN7938499

Cet anticorps Souris Monoclonal détecte spécifiquement SMC3 dans WB. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour SMC3 anticorps (acLys105, acLys106, C-Term) (ABIN7938499)

Antigène: SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SMC3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SMC3 anticorps

Épitope: acLys105, acLys106, C-Term

Fonction: SMC3 K105acK106ac antibody (mAb)

Purification: Protein G Chromatography

Immunogène: This SMC3 antibody was raised against a peptide in the C-terminal region of human SMC3.

Isotype: IgG1

Information d'application

Indications d'application: WB*: 1:500 - 1:1,000 dilution The addition of 0.05 % Tween 20 in the blocking buffer and primary antibody incubation buffer is recommended to aid in detection by Western blot. Individual optimization may be required.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS, 30 % glycerol, 0.035 % Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur SMC3

Antigène: SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))

Autre désignation: SMC3

Sujet:

Background_Plain: The Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression.SMC3 is a component of the cohesin complex that plays an essential role during chromatid segregation. SMC3 is also involved in DNA recombination and repair, mitotic chromosome organization and microtubule-mediated intracellular transport. SMC3 is acetylated during replication, which is essential for cohesion, and is phosphorylated by ATM after DNA double strand breakage. This antibody is acetylated at lysine 105/106.SMC3 is frequently elevated in human colon carcinoma and overexpression of the protein transforms fibroblasts.

Aliases: BAM, BMH, HCAP, CDLS3, CSPG6, SMC3L1

Poids moléculaire: 141 kDa

NCBI Accession: NP_005436

Pathways: Stem Cell Maintenance