YTHDF2 anticorps (C-Term)

N° du produit ABIN7938548

L’anticorps anti-YTHDF2 Polyclonal Lapin est utilisé pour la détection de YTHDF2 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour YTHDF2 anticorps (C-Term) (ABIN7938548)

Antigène: YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YTHDF2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-YTHDF2 anticorps

Épitope: C-Term

Fonction: YTHDF2 antibody (pAb)

Purification: Affinity Purified

Immunogène: This YTHDF2 antibody was raised against a fusion protein with His-tags at the C-terminus.

Isotype: IgG

Information d'application

Indications d'application: WB: 1 - 4 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS, 30 % glycerol, 0.035 % Azide. Sodium Azide is highly toxic.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur YTHDF2

Antigène: YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))

Autre désignation: YTHDF2

Sujet:

Background_Plain: YTHDF2 (YT521-B homology domain family 2, also known as CAHL, HGRG8, NY-REN-2) is a member of the YTH (YT521-B homology) superfamily containing YTH domain. Human YTH domain family proteins include three members, YTHDF1-3, which mainly localized in the cytoplasm. YTHDF proteins contain a highly conserved single-stranded RNA-binding domain which can specifically recognize and bind m6A-containing RNAs. An important role of YTHDF2is in regulating mRNA stability. YTHDF2 recognizes many m6A-containing mRNAs that are not being actively translated and recruits them to cytoplasmic processing (P) bodies for degradation. YTHDF2 preserves 5'UTR methylation of stress- induced transcripts and promotes cap-independent mRNA translation by competitive binding and limiting the m6A 'eraser' FTO from demethylation. N6-methylated adenine (m6A) is prevalently present in nearly all RNA types and can be found in all organisms from bacteria to humans. It preferentially appears around stop codons and within long internal exons in mammalian messager RNAs. m6A plays an important role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability. m6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs).

Aliases: YTH N6-Methyladenosine RNA Binding Protein 2, HGRG8

Poids moléculaire: 70 kDa

NCBI Accession: NP_057342