Recombinant YTHDF2 anticorps

N° du produit ABIN7938551

L’anticorps anti-YTHDF2 Monoclonal Lapin est utilisé pour la détection de YTHDF2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB.

Aperçu rapide pour Recombinant YTHDF2 anticorps (ABIN7938551)

Antigène: YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp YTHDF2 est non-conjugé

Application: Western Blotting (WB)

Clone: 3L6

Détail du produit anti-YTHDF2 anticorps

Fonction: YTHDF2 antibody (rAb), 100 μg (Clone 3L6)

Purification: Protein A Chromatography

Immunogène: This antibody was raised against the YTHDF2 fusion protein.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:5000-1:50000 dilution

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur YTHDF2

Antigène: YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))

Autre désignation: YTHDF2

Sujet:

Background_Plain: YTHDF2 (YT521-B homology domain family 2, also known as CAHL, HGRG8, NY-REN-2) is a member of the YTH (YT521-B homology) superfamily containing YTH domain. Human YTH domain family proteins include three members, YTHDF1-3, which mainly localized in the cytoplasm. YTHDF proteins contain a highly conserved single-stranded RNA-binding domain which can specifically recognize and bind m6A-containing RNAs. An important role of YTHDF2 is in regulating mRNA stability. YTHDF2 recognizes many m6A-containing mRNAs that are not being actively translated and recruits them to cytoplasmic processing (P) bodies for degradation. YTHDF2 preserves 5'UTR methylation of stress- induced transcripts and promotes cap-independent mRNA translation by competitive binding and limiting the m6A 'eraser' FTO from demethylation.

Aliases: YTH N6-Methyladenosine RNA Binding Protein 2, HGRG8

Poids moléculaire: 62 kDa