NT5DC3 anticorps (AA 52-548) (Fluoro550)

N° du produit ABIN7965168

Cet anticorps anti-NT5DC3 Polyclonal Lapin conjugué à Fluoro550 (ABIN7965168) détecte spécifiquement NT5DC3 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour NT5DC3 anticorps (AA 52-548) (Fluoro550) (ABIN7965168)

Antigène: NT5DC3 (5'-Nucleotidase Domain Containing 3 (NT5DC3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NT5DC3 est conjugé à/à la Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit anti-NT5DC3 anticorps (Fluoro550)

Épitope: AA 52-548

Fonction: Anti-NT5DC3 Antibody Fluoro550 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human NT5DC3 recombinant protein (Position: D52-K548).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur NT5DC3

Antigène: NT5DC3 (5'-Nucleotidase Domain Containing 3 (NT5DC3))

Autre désignation: NT5DC3

Sujet:

Background: 5'-Nucleotidase domain containing 2 (NT5DC2) is a member of the NT5DC family and contains a haloacid dehalogenase motif localized in the N-terminus of these proteins. NT5DC2 shows high sequence similarity with NT5C2. NT5C2 has received attention in the field of hematological neoplasms because NT5C2 mutations have been demonstrated to drive resistance to thiopurine, a drug frequently used to treat hematological neoplasms. NT5C2 catalyzes purine-nucleotide metabolism and induces chemotherapeutic resistance via excess export of purines to the extracellular space and depletion of the intracellular purine-nucleotide pool. Therefore, NT5DC2 may also participate in purine-nucleotide metabolism and exert purine-nucleotide catalytic activity. NT5DC2 overexpression promotes HCC cell proliferation and clone formation by regulating the cell cycle and promoting tumor growth in subcutaneous xenografts, while NT5DC2 knockdown inhibits these processes. NT5DC2 is associated with attention-deficit/hyperactivity disorder and bipolar disorder. NT5DC2 interacts with tyrosine hydroxylase (TH) to regulate TH catalytic activity and thus regulate catecholamine synthesis. NT5DC2 has been shown to interact with and stabilize Fyn, an Src family proto-oncogene, and plays a role in regulating glioblastoma progression.

Gene Full Name: 5'-nucleotidase domain containing 3

ID gène: 51559

UniProt: Q86UY8