Aconitase 1 anticorps (AA 1-137) (Fluoro594)

N° du produit ABIN7965587

L’anticorps anti-Aconitase 1 Polyclonal Lapin est utilisé pour la détection de Aconitase 1 dans des échantillons de Humain, Souris, Rat et Singe. Il a été validé pour FACS.

Aperçu rapide pour Aconitase 1 anticorps (AA 1-137) (Fluoro594) (ABIN7965587)

Antigène: Aconitase 1 (ACO1)

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aconitase 1 est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-Aconitase 1 anticorps (Fluoro594)

Épitope: AA 1-137

Fonction: Anti-Aconitase 1/ACO1 Antibody Fluoro594 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Aconitase 1/ACO1 recombinant protein (Position: M1-D137).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Aconitase 1

Antigène: Aconitase 1 (ACO1)

Autre désignation: ACO1

Sujet:

Background: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.

Gene Full Name: aconitase 1

ID gène: 48

UniProt: P21399

Pathways: Transition Metal Ion Homeostasis