ACE2 anticorps (AA 18-805) (Fluoro594)

N° du produit ABIN7968689

L’anticorps anti-ACE2 Polyclonal Lapin est utilisé pour la détection de ACE2 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour ACE2 anticorps (AA 18-805) (Fluoro594) (ABIN7968689)

Antigène: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACE2 est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-ACE2 anticorps (Fluoro594)

Épitope: AA 18-805

Fonction: Anti-ACE2 Antibody Fluoro594 Conjugated

Homologie: Human ACE2 shares 81.9%,82.8% amino acid (aa) sequence identity with mouse,rat ACE2,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ACE2 recombinant protein (Position: Q18-F805). Human ACE2 shares 81.9% and 82.8% amino acid (aa) sequence identity with mouse and rat ACE2, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur ACE2

Antigène: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Autre désignation: ACE2

Sujet:

Background: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible.

Gene Full Name: angiotensin converting enzyme 2

ID gène: 59272

UniProt: Q9BYF1

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour