Aquaporin 4 anticorps (AA 247-323) (Fluoro488)

N° du produit ABIN7969721

Cet anticorps anti-Aquaporin 4 Polyclonal Lapin conjugué à Fluoro488 (ABIN7969721) détecte spécifiquement Aquaporin 4 dans FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Aquaporin 4 anticorps (AA 247-323) (Fluoro488) (ABIN7969721)

Antigène: Aquaporin 4 (AQP4)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aquaporin 4 est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-Aquaporin 4 anticorps (Fluoro488)

Épitope: AA 247-323

Fonction: Anti-Aquaporin 4/AQP4 Antibody Fluoro488 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Aquaporin 4/AQP4 recombinant protein (Position: L247-V323).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Aquaporin 4

Antigène: Aquaporin 4 (AQP4)

Autre désignation: AQP4

Sujet:

Background: Aquaporin 4 is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. The gene of AQP4 is mapped to 18q11.2-q12.1. Similar to other aquaporins, the AQP4 gene is composed of 4 exons encoding 127, 55, 27, and 92 amino acids separated by introns of 0.8, 0.3, and 5.2 kb. Unlike other aquaporins, an alternative coding initiation sequence (designated exon 0) was located 2.7 kb upstream of exon 1. When spliced together, M1 and the subsequent 10 amino acids are encoded by exon 0, the next 11 amino acids and M23 are encoded by exon 1. AQP4 is expressed in astrocytes and is upregulated by insult to the central nervous system. And AQP4 is the predominant water channel in the brain and has an important role in brain water homeostasis. It is abundant in mammalian brain and is concentrated in astrocytic foot processes at the blood-brain barrier.

Gene Full Name: aquaporin 4

ID gène: 361

UniProt: P55087

Pathways: Sensory Perception of Sound