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MST1 anticorps (AA 385-487) (Cy3)

MST1 Reactivité: Humain, Souris, Rat WB, FACS, IF (cc), IF (p) Hôte: Lapin Polyclonal Cy3
N° du produit ABIN747311
  • Antigène Voir toutes MST1 Anticorps
    MST1 (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1))
    Épitope
    • 15
    • 10
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 385-487
    Reactivité
    • 82
    • 39
    • 33
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 77
    • 8
    Lapin
    Clonalité
    • 79
    • 6
    Polyclonal
    Conjugué
    • 29
    • 8
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MST1 est conjugé à/à la Cy3
    Application
    • 49
    • 27
    • 25
    • 23
    • 12
    • 12
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Homologie
    Dog,Cow,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human MST1
    Isotype
    IgG
    Top Product
    Discover our top product MST1 Anticorps primaire
  • Indications d'application
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    MST1 (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1))
    Autre désignation
    MST1 (MST1 Produits)
    Synonymes
    anticorps D3F15S2, anticorps DNF15S2, anticorps HGFL, anticorps MSP, anticorps NF15S2, anticorps E2F2, anticorps D3F15S2h, anticorps D9H3F15S2, anticorps DNF15S2h, anticorps Hgfl, anticorps HGF1/MSP, anticorps E1A, anticorps XHL, anticorps d3f15s2, anticorps dnf15s2, anticorps hgfl, anticorps msp, anticorps mst1, anticorps nf15s2, anticorps macrophage stimulating 1, anticorps macrophage stimulating 1 (hepatocyte growth factor-like), anticorps serine/threonine kinase 4, anticorps macrophage stimulating 1 L homeolog, anticorps MST1, anticorps Mst1, anticorps STK4, anticorps mst1.L
    Sujet

    Synonyms: KRS2, MST1, YSK3, TIIAC, Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1, MST-1, STE20-like kinase MST1, Serine/threonine-protein kinase Krs-2, STK4

    Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

    ID gène
    6789
    UniProt
    Q13043
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