Aryl Hydrocarbon Receptor anticorps (Middle Region) (Biotin)

N° du produit ABIN7970181

Cet anticorps Lapin Polyclonal détecte spécifiquement Aryl Hydrocarbon Receptor dans WB, IHC et ELISA. Il présente une réactivité avec des échantillons de Souris et Rat.

Aperçu rapide pour Aryl Hydrocarbon Receptor anticorps (Middle Region) (Biotin) (ABIN7970181)

Antigène: Aryl Hydrocarbon Receptor (AHR)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aryl Hydrocarbon Receptor est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-Aryl Hydrocarbon Receptor anticorps (Biotin)

Épitope: Middle Region

Fonction: Anti-Aryl hydrocarbon Receptor/AHR Antibody Biotin Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related human sequence by five amino acids,and from the related rat sequence by one amino acid.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of mouse AHR, different from the related human sequence by five amino acids, and from the related rat sequence by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Aryl Hydrocarbon Receptor

Antigène: Aryl Hydrocarbon Receptor (AHR)

Autre désignation: Ahr

Sujet:

Background: AHR (aryl hydrocarbon receptor), also called bHLHe76, is a member of the family of basic helix-loop-helix transcription factors. AhR is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. The AHR gene is mapped on 7p21.1. Estrogenic actions of AHR agonists were detected in wildtype ovariectomized mouse uteri, but were absent in Ahr -/- or Er-alpha -/- ovariectomized mice. Complex assembly and ubiquitin ligase activity of CUL4B (AHR) in vitro and in vivo are dependent on the AHR ligand. In the CUL4B (AHR) complex, ligand-activated AHR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation. Cd4-positive cells from mice lacking Ahr developed Th17 responses but failed to produce Il22 and did not show enhanced Th17 development. Activation of Ahr during induction of EAE accelerated disease onset and increased pathology in wildtype mice, but not in Ahr -/- mice. The TDO-AHR pathway is active in human brain tumors and is associated with malignant progression and poor survival. Ahr activity within ROR-gamma-t-positive ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae.

Gene Full Name: aryl-hydrocarbon receptor

Sequence Similarities: Contains 1 bHLH (basic helix-loop-helix) domain.

ID gène: 11622

UniProt: P30561

Pathways: Regulation of Cell Size