BAG2 anticorps (AA 1-211) (APC)

N° du produit ABIN7972317

Cet anticorps Lapin Polyclonal détecte spécifiquement BAG2 dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour BAG2 anticorps (AA 1-211) (APC) (ABIN7972317)

Antigène: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAG2 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-BAG2 anticorps (APC)

Épitope: AA 1-211

Fonction: Anti-BAG2 Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human BAG2 shares 93.4% amino acid (aa) sequence identity with mouse BAG2.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human BAG2 recombinant protein (Position: M1-N211). Human BAG2 shares 93.4% amino acid (aa) sequence identity with mouse BAG2.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur BAG2

Antigène: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Autre désignation: BAG2

Sujet:

Background: BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.

Gene Full Name: BAG cochaperone 2

Sequence Similarities: Contains 1 P-type (trefoil) domain.

ID gène: 9532

UniProt: O95816