CASR anticorps (AA 926-1078) (PE)

N° du produit ABIN7974146

Cet anticorps anti-CASR Monoclonal Souris conjugué à PE (Clone 11E9) (ABIN7974146) détecte spécifiquement CASR dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CASR anticorps (AA 926-1078) (PE) (ABIN7974146)

Antigène: CASR (Calcium-Sensing Receptor (CASR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CASR est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Clone: 11E9

Détail du produit anti-CASR anticorps (PE)

Épitope: AA 926-1078

Fonction: Anti-CASR Antibody (monoclonal, 11E9) PE Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: coli-derived human CASR recombinant protein (Position: Q926-S1078). Human CASR shares 80.5%,78.6% amino acid (aa) sequence identity with mouse,rat CASR,respectively.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human CASR recombinant protein (Position: Q926-S1078). Human CASR shares 80.5% and 78.6% amino acid (aa) sequence identity with mouse and rat CASR, respectively.

Isotype: IgG2b

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur CASR

Antigène: CASR (Calcium-Sensing Receptor (CASR))

Autre désignation: CASR

Sujet:

Background: The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Gene Full Name: calcium sensing receptor

ID gène: 846

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis