CAMKK1 anticorps (N-Term) (APC)

N° du produit ABIN7974189

Cet anticorps Lapin Polyclonal détecte spécifiquement CAMKK1 dans FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CAMKK1 anticorps (N-Term) (APC) (ABIN7974189)

Antigène: CAMKK1 (Calcium/calmodulin-Dependent Protein Kinase Kinase 1, alpha (CAMKK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CAMKK1 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-CAMKK1 anticorps (APC)

Épitope: N-Term

Fonction: Anti-CaMKK/CAMKK1 Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related human sequence by three amino acids,and from the related rat sequence by two amino acids.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of mouse CaMKK, different from the related human sequence by three amino acids, and from the related rat sequence by two amino acids.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur CAMKK1

Antigène: CAMKK1 (Calcium/calmodulin-Dependent Protein Kinase Kinase 1, alpha (CAMKK1))

Autre désignation: CAMKK1

Sujet:

Background: CAMKK1, Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene. The CAMKK1 gene is mapped to chromosome 17. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca (2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.Camkk1binds calmodulin and activated Camk4 with a 6-fold increase in total activity and a 100-fold increase in Camk4 Ca (2+)-independent activity. Camkk1 catalyzed a 10-fold increase in the total activity of Camk1 and had no effect on Camk2. Cotransfection of COS-7 cells with Camkk1 and Camk4 resulted in a 14-fold increase in CRE-binding protein-dependent transcription compared with Camk4 alone, suggesting that Camkk1 enhances Camk4-mediated transcriptional regulation.

Gene Full Name: calcium/calmodulin-dependent protein kinase kinase 1, alpha

Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

ID gène: 55984

UniProt: Q8VBY2

Pathways: AMPK Signaling